What is Tesofensine?
Tesofensine is a serotonin-noradrenaline- dopamine reuptake inhibitor, which is being developed for the treatment of obesity. Tesofensine was originally being investigated for the treatment of Parkinson’s disease and Alzheimer’s disease. However, significant weight loss was consistently reported as an adverse event in the original studies. For this reason, it was decided to pursue development ofTesofensine as a treatment for obesity.
How does Tesofensine work?
Tesofensine, primarily, acts as an appetite suppressant and could increase resting energy expenditure. Phase II trials for the treatment of obesity with Tesofensine have been completed. On average, its 6 month weight loss results from a phase 2b clinical trial resulted in a weight loss of around 25 pds.
What forms of Tesofensine are available?
Tesofensine is given in 500mcg oral capsules. Take one capsule by mouth once daily in the morning.
Who should use Tesofensine?
Patients that are having difficulty maintaining a healthy weight or struggling with obesity. Tesofensine offers a safe weight loss option without the cardiac risks or serious side effects associated with other drugs promoting weight loss.
What You Need to Know:
This medication should not be used with any other reuptake inhibitors or SSRls. The most commonly reported side effects in the obese population are: dry mouth, headache, nausea, diarrhea, and constipation.
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